"The
Report Frontier Pharma: Pancreatic Cancer - Identifying and
Commercializing First-in-Class Innovation provides information on
pricing, market analysis, shares, forecast, and company profiles for
key industry participants. - MarketResearchReports.biz"
Pancreatic
cancer
is the 12th most common cancer globally, and the fourth most fatal,
with a mortality rate of 10.9 deaths per 100,000 people per year. The
poor prognosis of pancreatic cancer patients has highlighted a
significant need for new and improved approaches to treatment, which
is not being met by the current market.
A highly active pancreatic
cancer pipeline contains an array of products with varying molecule
types and mechanisms of action, which provides a striking contrast to
the current, chemotherapy dominated, market. Within the pipeline,
there are 185 products that act on a first-in-class molecular target,
representing 52% of the total pancreatic cancer pipeline products
that have a disclosed molecular target. A drastically different
pipeline and market composition implies that the approach to
pancreatic cancer treatment is changing and first-in-class innovation
is playing a significant role in this.
Download
Sample copy of this Report at :
http://www.marketresearchreports.biz/sample/sample/294920
Scope
- Gemcitabine based regimens continue to dominate the market, which has seen few new entrants over the past decade. The continued reliance on generic chemotherapies is one reason why the prognosis has shown little improvement.
- What survival benefits do current therapies provide?
- What are the current unmet needs that the pipeline needs to address?
- The pipeline contains a plethora of molecule types and molecular targets not present on the market, including a large focus on therapies targeting common oncogenic pathways and signaling intermediates such as PI3K/Akt.
- What impact will the emergence of biologics have on the pancreatic cancer landscape?
- Will pipeline diversity translate to clinically and commercially successful therapies?
- How will the rise of novel molecular target categories, such as signal transduction, impact future treatment options?
- 52% of pipeline products act on a first-in-class target, which is higher than the oncology and industry averages.
- Do first-in-class products show strong progression into the later stages?
- Why is the greatest number of first-in-class products seen in signal transduction?
- Numerous early-stage, first-in-class products have high promise, often supported by preclinical evidence.
- How well are first-in-class targets, such as Akt2, aligned to known disease causing pathways?
- Does scientific literature provide significant rationale for therapies acting on early-stage promising, first-in-class targets?
- What does preclinical data on Akt inhibition suggest about its potential as a target in pancreatic cancer?
- Deals for first-in-class products typically take place in earlier stages than non-first-in-class counterparts, with 79% of first-in-class licensing deals occurring in Phase I or earlier.
- To what extent does first-in-class status influence deal value?
- Can biologics command a greater deal value than other molecule types?
Reasons to buy
This report will allow you to
- Understand the current clinical and commercial landscape. This includes a comprehensive study of disease pathogenesis, diagnosis, prognosis and the available treatment options available at each stage of diagnosis.
- Visualize the composition of the pancreatic cancer market in terms of dominant molecule types and targets, highlighting what the current unmet needs are and how they can be addressed. This knowledge allows a competitive understanding of gaps in the current market.
- Analyze the pancreatic cancer pipeline, and stratify by stage of development, molecule type and molecular target. There are promising signs in the pipeline that the industry is seeking novel approaches the treating pancreatic cancer.
- Assess the therapeutic potential of first-in-class targets. Using a proprietary matrix, first-in-class products have been assessed and ranked according to clinical potential.Promising targets, including MAP3K7 and P70-S6 Kinase 1 have been extensively reviewed using peer-reviewed literature and preclinical data.
- Identify commercial opportunities in the pancreatic cancer deals landscape by analyzing trends in licensing and co-development deals and producing a curated list of pancreatic cancer therapies that are not yet involved in deals and may be potential investment opportunities.
Follow
us on LinkedIn:
https://www.linkedin.com/company/marketresearchreports-biz
Table of Contents
1 Table of Contents 2
1.1 List of Tables 3
1.2 List of Figures 3
2 Executive Summary 4
2.1 Large and Diverse Pipeline
Contrasts the Limited Market 4
2.2 Pancreatic Cancer Shows
High Levels of First-in-Class Innovation 4
2.3 High Deal Activity Reflects
Dynamic Pipeline 4
3 The Case for Innovation 5
3.1 Growing Opportunities for
Biologic Products 6
3.2 Diversification of
Molecular Targets 6
3.3 Innovative First-in-Class
Product Developments Remain Attractive 6
3.4 Regulatory and
Reimbursement Policy Shifts Favor First-in-Class Product Innovation 7
3.5 Sustained Innovation 7
3.6 GBI Research Report
Guidance 8
4 Clinical and Commercial
Landscape 9
4.1 Disease Overview 9
4.2 Disease Symptoms 9
4.3 Epidemiology 9
4.4 Etiology 10
4.4.1 Risk Factors 10
4.4.2 Medical Conditions
Leading to Pancreatic Cancer 10
4.4.3 Genetic Conditions
Leading to Pancreatic Cancer 10
4.4.4 Conclusion 11
4.5 Pathophysiology 11
4.5.1 Frequently Dysregulated
Pathways 11
4.5.2 Oncogenes 12
4.5.3 Tumor Suppressor Genes 13
4.6 Diagnosis 13
4.7 Prognosis 14
4.8 Treatment Options 14
4.8.1 Surgery 14
4.8.2 Radiation therapy 14
4.8.3 Chemotherapy 15
4.9 Chemotherapeutic Treatment
Algorithm 16
4.9.1 Adjuvant Chemotherapy in
Operable Early-Stage Disease 16
4.9.2 First-Line Treatment of
Inoperable Advanced Disease 18
4.9.3 Second-Line Therapy in
Inoperable Advanced Disease 25
4.10 Overview of Marketed
Products in Pancreatic Cancer 26
4.10.1 Molecule Type and Target
Analysis 26
4.10.2 Innovative Products in
the Pancreatic Cancer Market 27
4.10.3 Unmet Needs 28
5 Assessment of Pipeline
Product Innovation 29
5.1 Pancreatic Cancer Pipeline
by Molecule Type, Phase and Therapeutic Target 29
5.2 Comparative Distribution of
Programs between the Pancreatic Cancer Market and Pipeline by
Therapeutic Target Family 34
5.3 First-in-Class Pipeline
Programs Targeting Novel Molecular Targets 35
About
us
MarketResearchReports.biz
is the most comprehensive collection of market research reports.
MarketResearchReports.Biz services are specially designed to save
time and money for our clients. We are a one stop solution for all
your research needs, our main offerings are syndicated research
reports, custom research, subscription access and consulting
services. We serve all sizes and types of companies spanning across
various industries.
Contact
Mr.
Nachiket
State
Tower
90
Sate Street, Suite 700
Albany,
NY 12207
Tel:
+1-518-621-2074
No comments:
Post a Comment