"The Report Seasonal
Influenza Therapeutics in Asia-Pacific Markets to 2022 - Growth
Driven by Rising Elderly Population, Growing Awareness and Launch of
Quadrivalent Therapies provides information on pricing, market
analysis, shares, forecast, and company profiles for key industry
participants. - MarketResearchReports.biz"
Influenza, often referred to as
the flu, is an acute infection caused by one of the three closely
related viruses, designated as influenza Type A, B, and C. The
infection’s rapid onset and potential for high morbidity and
mortality, particularly in high-risk patient populations such as the
elderly and young children, make prompt and effective treatment with
antiviral medication very difficult. For these reasons, prophylactic
vaccination is the preferred intervention for seasonal influenza.
In the recent years it was
observed that demand for seasonal influenza vaccines have increased
due to changed perception of patient population. APAC region is an
attractive market for seasonal influenza vaccine manufacturers.
Continuous improvements in the formulation of vaccines has occurred
over the years, with the market currently transitioning from
trivalent to quadrivalent formulations, which offer protection
against an additional B strain of the virus. Traditional egg based
manufacturing of seasonal influenza vaccines is being replaced with
cell culture vaccines. Cell culture based production of vaccines is
expected to reduce the problems associated with the production and
use of seasonal influenza vaccines which will further increase the
vaccination coverage in the APAC region.
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GBI Research’s analysis shows
that the R&D pipeline for seasonal influenza vaccines comprises a
high number of vaccines in early-stage development, many of which are
new formulations or those that have been developed using the cell
culture method. Late-stage vaccines are either quadrivalent vaccines
or pediatric versions of those that have already been approved. GBI
Research expects that quadrivalent seasonal influenza vaccines will
replace their trivalent vaccines forerunner by the end of the
forecast period.
Scope
The seasonal influenza
Asia-Pacific market will be valued at $1.71 billion in 2022, growing
from $1.24 billion in 2015 at a CAGR of 4.7%.
Trivalent and quadrivalent
vaccines dominate the seasonal influenza market, but unmet needs
exist in terms of safety and efficacy.
- Will the drugs under development fulfill the unmet needs of the seasonal influenza market?
- Do quadrivalent therapies show continuous growth, and are they facing any competition from trivalent therapies?
- How will available therapies be affected by upcoming pipeline therapies?
The pipeline contains a range
of molecule types and molecular targets, including those that are
well established in seasonal influenza.
- Which molecular targets appear most frequently in the pipeline?
- Will the pipeline drugs fulfill the unmet needs of seasonal influenza market?
Market forecasts indicate that
Japan will contribute the most to the Asia-Pacific market value, due
to the emergence of quadrivalent therapies.
- How will the annual cost of therapy and market size vary between the five Asia-Pacific markets?
Various drivers and barriers
will influence the market over the forecast period.
- What barriers limit the uptake of premium-priced vaccines in the assessed countries?
- What factors are most likely to drive the market in these countries?
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Reasons to buy
This report will allow you to -
- Understand the current clinical and commercial landscape by considering disease pathogenesis, diagnosis, prognosis, and the treatment options available at each stage of diagnosis, including a clinical comparison of marketed therapies.
- Visualize the composition of the seasonal influenza market in terms of dominant therapies, with their clinical and commercial standing. Unmet needs are highlighted to allow a competitive understanding of gaps in the current market.
- Analyze the seasonal influenza pipeline and stratify pipeline therapies by stage of development, molecule type and molecular target.
- Understand the potential of late-stage therapies, with extensive profiles of products that could enter the market over the forecast period, highlighting clinical performance, potential commercial positioning, and how they will compete with other therapies.
- Predict seasonal influenza market growth in the five Asia-Pacific markets, with epidemiological and annual cost of therapy forecasts across India, China, Australia, South Korea and Japan, as well as analysis of the contributions of promising late-stage molecules to market growth.
- Identify commercial opportunities in the seasonal influenza deals landscape by analyzing trends in licensing and co-development deals.
Table of Contents
1 Table of Contents
1 Table of Contents 4
1.1 List of Tables 7
1.2 List of Figures 7
2 Introduction 9
2.1 Disease Introduction 10
2.2 Epidemiology 10
2.3 Symptoms 12
2.4 Etiology and Pathophysiology
13
2.4.1 Pathophysiology 14
2.5 Diagnosis 14
2.6 Prognosis 16
2.7 Treatment Options 17
2.7.1 Treatment Algorithm 17
2.7.2 Pharmacological Treatments
19
2.7.3 Non-pharmacological
Treatments 21
2.7.4 Exercise 21
2.7.5 Dietary Interventions 22
3 Marketed Products 23
3.1 Overview 23
3.2 Fluarix Tetra -
GlaxoSmithKline 23
3.3 FluQuadri - Sanofi Pasteur 25
3.4 Vaxigrip - Sanofi Pasteur 25
3.5 Agrippal - CSL 26
3.6 Fluad - CSL 27
3.7 Fluvax/Afluria - CSL 27
3.8 Optaflu - CSL 28
3.9 Influvac - Abbott 29
3.10 GC Flu - Green Cross
Corporation 29
3.11 Intanza/IDflu - Sanofi
Pasteur 30
3.12 SkyCellflu - SK Chemicals 31
3.13 Nasovac-S - Serum Institute
of India 31
3.14 Comparative Efficacy and
Safety of Marketed Products 32
4 Pipeline Analysis 34
4.1 Overview 34
4.2 Pipeline by Stage of
Development, Molecule Type, Route of Administration and Program Type
35
4.3 Pipeline by Molecular Target
37
4.4 Promising Pipeline Candidates
39
4.4.1 VN-100 - Daiichi Sankyo 39
4.4.2 ASP7374 (UMN-0502) - UMN
Pharma 41
4.4.3 MEDI3250 (VN-0107) - Daiichi
Sankyo 43
4.5 Comparative Efficacy and
Safety of Pipeline Products 45
4.6 Product Competitiveness
Framework 45
5 Clinical Trial Analysis 47
5.1 Failure Rate 47
5.1.1 Overall Failure Rate 47
5.1.2 Failure Rate by Phase and
Molecule Type 48
5.1.3 Failure Rate by Phase and
Molecular Target 49
5.2 Clinical Trial Duration 51
5.2.1 Clinical Trial Duration by
Molecule Type 51
5.2.2 Clinical Trial Duration by
Molecular Target 52
5.3 Clinical Trial Size 53
5.3.1 Patient Enrollment per
Product by Molecule Type, Molecular Target and Stage of Development
53
5.3.2 Patient Enrollment per Trial
by Molecule Type, Molecular Target and Stage of Development 55
5.4 Competitive Clinical Trials
Metrics Analysis 57
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